Day 1 : Istanbul/TURKEY

Once called Constantinople, the former capital of the Byzantine Empire is the only city in the world to straddle two continents: Europe and Asia. This is the Golden Horn, the door between East and West, and your first vision of its domes and minarets is unforgetable. Hagia Sophia, the Blue Mosque and Sultan treasures in Topkapi Palace await - as does the Grand Bazaar, laden with carpets, beaten brass and spices from afar.

Day 2 :

Dikili is the port for the ancient mountain citadel of Pergamum where you can visit Asklepeion, the site where psychiatry was first practiced. Also see the Sacred Pools, the Altar of Zeus, the Library, and the Serpent Altar which still serves as the symbol of the medical profession.

Day 3 : Ephesus/TURKEY

Day 4 : Mykonos/GREECE

The narrow passageways of Mykonos are a twisted maze of whitewashed houses, miniature churches, lazy windmills, and tiny cafes serving up Greek specialties. Sample the freshest squid or lobster just snatched from the blue Aegean Sea, or shop for typical flokati rugs.

Day 5 : At Sea

Day 6 : Rhodes/GREECE

Legend has it that Apollo blessed this isle with sunshine and beauty. True to the myths, the "Island of Roses" is rich in magnificent scenery and umbrella-lined beaches. Take an excursion to Lindos, where high on a hill rises an ancient acropolis dedicated to the goddess Athena. You will also want to see the medieval Old Town, once home to the Crusading Knights of St. John, and tour the Grand Master's Palace, an Italian restoration famed for its superb mosaic floors.

Day 7 :

Day 8 : Limassol/CYPRUS

The birthplace of Aphrodite, the goddess of love and beauty, is nearby on this island - the third largest in Europe. Explore what is now called the Medieval Museum, a restored castle where Richard the Lionheart married in 1191. Visit a mosque, browse the local artisan shops and take in the natural and architectural delights of Cyprus.

Day 9 : At Sea

Day 10 : Heraklion

Heraklion, the capital of Crete and its principal commercial port, is just three miles away from the fantastic ruins of the Palace of Knossos. Discovered in 1899 by Sir Arthur Evans and partially reconstructed, the elaborate Palace is believed to be the mythical Labyrinth of King Minos and the seat of ancient Minoan culture. The Archaeological Museum in Heraklion displays many of the treasures found during the excavations.

Day 11 : Athens/GREECE

Piraeus is the seaport for Athens, the capital of western civilization, which boasts a fantastic mix of classical ruins and vivacious modern life. In a single day, you can climb the hill of the Acropolis to wonder at the Parthenon, join the lively Athenians in Constitution Square, and then find a welcoming taverna for some spirited bizouki music, plenty of ouzo to drink, and with luck, energetic Greek dancing.

Day 12 : Santorini/GREECE

With its steep volcanic flanks looming straight up from the sea, and the tiny white village of Thira clinging high atop the cliffs, Santorini is perhaps the most breathtaking and legendary of all the Greek Isles. To the south is Akrotiri, where recent Minoan excavations support the theories that Santorini might be the fabled lost continent of Atlantis.

Day 13 : At Sea

Day 14 : Alexandria/EGYPT

Founded by Alexander the Great in 331 B.C., Alexandria is Egypt's center of culture, learning and science. Its lighthouse, the world's first, was one of the Seven Wonders of the Ancient World. Alexandria is also the departure point for excursions to Cairo and the Pyramids.

Day 15 :

It is a massive cosmopolitan city where the past and the present coexist in perfect harmony... A brief 30-minute cab ride from the center of the city will take you to the home of the most popular pyramids of Giza. Here dwells the great Sphinx that has become the second flag of Egypt.

Day 16 : Jerusalem/ISRAEL

Perched on sand dunes, Ashdod is a gateway to the Holy Land. From here, you can journey to Jerusalem and Bethlehem and walk the Via Dolorosa and see the stations of the cross. Among the many other sites of interest are the Western Wall, the Church of the Holy Sepulcher and, in Bethlehem, the Church of the Nativity.

Day 17 : Haifa/ISRAEL

A lovely seaport in its own right, Haifa is a departure point for Tel Aviv and Holy Land sightseeing. Jerusalem beckons with the Mount of Olives and the Western Wall. Jericho, Nazareth, Bethlehem, and the crusader city of Acre are also within reach.

Day 18 : At Sea

Day 19 : Ephesus/TURKEY

Day 20 : Istanbul/TURKEY

Once called Constantinople, the former capital of the Byzantine Empire is the only city in the world to straddle two continents: Europe and Asia. This is the Golden Horn, the door between East and West, and your first vision of its domes and minarets is unforgetable. Hagia Sophia, the Blue Mosque and Sultan treasures in Topkapi Palace await - as does the Grand Bazaar, laden with carpets, beaten brass and spices from afar.

Day 21 : Istanbul/TURKEY

Once called Constantinople, the former capital of the Byzantine Empire is the only city in the world to straddle two continents: Europe and Asia. This is the Golden Horn, the door between East and West, and your first vision of its domes and minarets is unforgetable. Hagia Sophia, the Blue Mosque and Sultan treasures in Topkapi Palace await - as does the Grand Bazaar, laden with carpets, beaten brass and spices from afar.