Day 1 : Istanbul/TURKEY

Once called Constantinople, the former capital of the Byzantine Empire is the only city in the world to straddle two continents: Europe and Asia. This is the Golden Horn, the door between East and West, and your first vision of its domes and minarets is unforgetable. Hagia Sophia, the Blue Mosque and Sultan treasures in Topkapi Palace await - as does the Grand Bazaar, laden with carpets, beaten brass and spices from afar.

Day 2 : Istanbul/TURKEY

Once called Constantinople, the former capital of the Byzantine Empire is the only city in the world to straddle two continents: Europe and Asia. This is the Golden Horn, the door between East and West, and your first vision of its domes and minarets is unforgetable. Hagia Sophia, the Blue Mosque and Sultan treasures in Topkapi Palace await - as does the Grand Bazaar, laden with carpets, beaten brass and spices from afar.

Day 3 : Izmir

Day 4 : Kos/GREECE

Kos is known as the home of Hippocrates, father of medical science. The town is an archeological repository of Archaic, Classical, Hellenistic, and Roman ruins. Take a tour to the ancient Asklepeion and the island's archaeological museum.

Day 5 : Antalya

This fortified seaport was already centuries old when St. Paul and St. Barnabas left its harbor on their journey to Antioch. Explore the superb museum in a converted Byzantine church, visit the ancient Roman Theatre, or simply relax amid the pleasant scents of orange groves and pine forests. Those hungry for more history can venture to the ancient towns of Side and Perge.

Day 6 : Heraklion

Heraklion, the capital of Crete and its principal commercial port, is just three miles away from the fantastic ruins of the Palace of Knossos. Discovered in 1899 by Sir Arthur Evans and partially reconstructed, the elaborate Palace is believed to be the mythical Labyrinth of King Minos and the seat of ancient Minoan culture. The Archaeological Museum in Heraklion displays many of the treasures found during the excavations.

Day 7 : At Sea

Day 8 : Valletta/MALTA

The Knights of St. John made this their base in the Mediterranean Sea. The castles, cathedrals and fortresses they built still are their remaining legacy. But Phoenicians, Romans, Carthaginians and Arabs preceded them and left their marks as well. Take a drive to M''dina, the former capital, and wonder at Europe''s third-largest dome in Mostra.

Day 9 : Sicily/ITALY

With the smoking cone of Mt. Etna as a backdrop, the chic resort of Taormina, is absolutely stunning. The town's ancient Greek theater is a wonder. Built in the third century B.C., with apparently perfect acoustics, it is still used today for open-air concerts. Spend some leisurely time along the Corso Umberto, where there are many interesting places to shop and dine.

Day 10 : Sorrento/ITALY

Some of Italy's most romantic villages cling to the dramatic slopes of the ruggedly beautiful Amalfi Coast. Sorrento's one so beautiful it inspired a song. Take a drive along the scenic coastal road. Or venture further, to the amazing ruins of Pompeii, uncovered from the ashes of Vesuvius, or to Capri, known as the "Island of Love."

Day 11 : Rome/ITALY

The port of Civitavecchia is the gateway to The Eternal City, where all roads lead. Mad traffic careens past monuments of the great civilizations of the past. You will want to see it all: the soaring inspiration of St. Peter's, the Vatican and the Sistine Chapel; the flow of life along the Spanish Steps, the Coliseum, the Via Veneto and Trevi Fountain. Be sure to leave time for la dolce vita in one of the piazzas.

Day 12 : Amalfi/ITALY

Amalfi is on Italy's western coast, facing the Mediterranean Sea. Nearby is Mt. Vesuvius, the volcano that buried the ancient city of Pompeii. The island of Capri is just offshore. Naples, the region's largest city, lies northwest of Amalfi.

Day 13 : Catania/ITALY

Steep, rugged Sicily had bred a race of fierce, funny and passionate people. From this important port, drive up the coast to visit Taormina. First Greeks, then Romans used this as a place of worship and reward. View the temples and the theater, Mt. Etna in the distance, or take a stroll and shop in the little village before you leave.

Day 14 : At Sea

Day 15 : At Sea

Day 16 : Athens/GREECE

Piraeus is the seaport for Athens, the capital of western civilization, which boasts a fantastic mix of classical ruins and vivacious modern life. In a single day, you can climb the hill of the Acropolis to wonder at the Parthenon, join the lively Athenians in Constitution Square, and then find a welcoming taverna for some spirited bizouki music, plenty of ouzo to drink, and with luck, energetic Greek dancing.

Day 17 : Santorini/GREECE

With its steep volcanic flanks looming straight up from the sea, and the tiny white village of Thira clinging high atop the cliffs, Santorini is perhaps the most breathtaking and legendary of all the Greek Isles. To the south is Akrotiri, where recent Minoan excavations support the theories that Santorini might be the fabled lost continent of Atlantis.

Day 18 : Rhodes/GREECE

Legend has it that Apollo blessed this isle with sunshine and beauty. True to the myths, the "Island of Roses" is rich in magnificent scenery and umbrella-lined beaches. Take an excursion to Lindos, where high on a hill rises an ancient acropolis dedicated to the goddess Athena. You will also want to see the medieval Old Town, once home to the Crusading Knights of St. John, and tour the Grand Master's Palace, an Italian restoration famed for its superb mosaic floors.

Day 19 : Limassol/CYPRUS

The birthplace of Aphrodite, the goddess of love and beauty, is nearby on this island - the third largest in Europe. Explore what is now called the Medieval Museum, a restored castle where Richard the Lionheart married in 1191. Visit a mosque, browse the local artisan shops and take in the natural and architectural delights of Cyprus.

Day 20 : Jerusalem/ISRAEL

Perched on sand dunes, Ashdod is a gateway to the Holy Land. From here, you can journey to Jerusalem and Bethlehem and walk the Via Dolorosa and see the stations of the cross. Among the many other sites of interest are the Western Wall, the Church of the Holy Sepulcher and, in Bethlehem, the Church of the Nativity.

Day 21 : Haifa/ISRAEL

A lovely seaport in its own right, Haifa is a departure point for Tel Aviv and Holy Land sightseeing. Jerusalem beckons with the Mount of Olives and the Western Wall. Jericho, Nazareth, Bethlehem, and the crusader city of Acre are also within reach.

Day 22 : Haifa/ISRAEL

A lovely seaport in its own right, Haifa is a departure point for Tel Aviv and Holy Land sightseeing. Jerusalem beckons with the Mount of Olives and the Western Wall. Jericho, Nazareth, Bethlehem, and the crusader city of Acre are also within reach.